Neutral Evolution of Model Proteins: Diffusion in Sequence Space and Overdispersion
نویسندگان
چکیده
منابع مشابه
Neutral evolution of model proteins: diffusion in sequence space and overdispersion.
We stimulate the evolution of model protein sequences subject to mutations. A mutation is considered neutral if it conserves (1) the structure of the ground state, (2) its thermodynamic stability and (3) its kinetic accessibility. All other mutations are considered lethal and are rejected. We adopt a lattice model, amenable to a reliable solution of the protein folding problem. We prove the exi...
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The process of ‘Evolutionary Diffusion’, i.e. reproduction with local mutation but without selection in a biological population, resembles standard Diffusion in many ways. However, Evolutionary Diffusion allows the formation of localized peaks that undergo drift, even in the infinite population limit. We relate a microscopic evolution model to a stochastic model which we solve fully. This allow...
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It is well known amongst molecular biologists that proteins with a common ancestor and that perform the same function in similar organisms, can have rather different amino-acid sequences. Mutations have altered the amino-acid sequences without affecting the function. A simple model of a protein in which the interactions are encoded by sequences of bits is introduced, and used to study how mutat...
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ژورنال
عنوان ژورنال: Journal of Theoretical Biology
سال: 1999
ISSN: 0022-5193
DOI: 10.1006/jtbi.1999.0975